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Urol Res. 2011 Oct;39(5):417-9. doi: 10.1007/s00240-011-0364-z. Epub 2011 Feb 18.

Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch-Nyhan syndrome.

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1
Department of Urology, Korea University Hospital, 80, Guro-dong, Guro-ku, Seoul 152-703, Republic of Korea.

Abstract

Lesch-Nyhan syndrome is a rare sex-linked disorder of purine metabolism that is caused by a mutation in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene which causes marked hyperuricemia and hyperuricosuria, with signs of gouty arthritis and uric acid stone disease in early childhood. We report a case of renal pelvis calculi which was dissolved within 10 days of urine alkalinization and hydration.

PMID:
21331772
DOI:
10.1007/s00240-011-0364-z
[Indexed for MEDLINE]
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