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J Biomed Biotechnol. 2011;2011:797383. doi: 10.1155/2011/797383. Epub 2011 Jan 26.

Experimental trauma models: an update.

Author information

1
Trauma Department, Hannover Medical School, Carl-Neuberg-Stra├če 1, 30625 Hannover, Germany. michaelfrink@web.de

Abstract

Treatment of polytrauma patients remains a medical as well as socioeconomic challenge. Although diagnostics and therapy improved during the last decades, multiple injuries are still the major cause of fatalities in patients below 45 years of age. Organ dysfunction and organ failure are major complications in patients with major injuries and contribute to mortality during the clinical course. Profound understanding of the systemic pathophysiological response is crucial for innovative therapeutic approaches. Therefore, experimental studies in various animal models are necessary. This review is aimed at providing detailed information of common trauma models in small as well as in large animals.

PMID:
21331361
PMCID:
PMC3035380
DOI:
10.1155/2011/797383
[Indexed for MEDLINE]
Free PMC Article

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