Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biomed Biotechnol. 2011;2011:464701. doi: 10.1155/2011/464701. Epub 2011 Jan 23.

Middle cerebral artery occlusion model in rodents: methods and potential pitfalls.

Author information

1
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA.

Abstract

A variety of animal models have been developed for modeling ischemic stroke. The middle cerebral artery occlusion (MCAO) model has been utilized extensively, especially in rodents. While the MCAO model provides stroke researchers with an excellent platform to investigate the disease, controversial or even paradoxical results are occasionally seen in the literature utilizing this model. Various factors exert important effects on the outcome in this stroke model, including the age and sex of the animal examined. This paper discusses emerging information on the effects of age and sex on ischemic outcomes after MCAO, with an emphasis on mouse models of stroke.

PMID:
21331357
PMCID:
PMC3035178
DOI:
10.1155/2011/464701
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center