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Nat Rev Neurosci. 2011 Mar;12(3):169-82. doi: 10.1038/nrn2995.

Engaging neuroscience to advance translational research in brain barrier biology.

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1
Oregon Health & Science University, 3181 SW Sam Jackson Park Road L603, Portland, Oregon 97239-2941, USA.

Abstract

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

PMID:
21331083
PMCID:
PMC3335275
DOI:
10.1038/nrn2995
[Indexed for MEDLINE]
Free PMC Article
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