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Shock. 2011 Jun;35(6):585-9. doi: 10.1097/SHK.0b013e31820fe4b7.

A-to-I RNA editing is induced upon hypoxia.

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Department of Pediatric Critical Care Medicine, Safra Children's Hospital, Tel Hashomer, Israel.


Regulating gene expression is part of a cell's response to hypoxia. A-to-I RNA editing is an epigenetic phenomenon that can contribute to RNA and protein levels and to isoform diversity. In this study, we identified alterations in the levels of RNA editing following hypoxic stress in three genes: MED13, STAT3, and F11R. Changes in editing levels were associated with changes in RNA levels. These results suggest that A-to-I RNA editing may be one of the mechanisms used by cells to regulate changes in gene expression after hypoxia. These findings could lead to a novel therapeutic approach and better health care for children with hypoxemia.

[Indexed for MEDLINE]

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