Format

Send to

Choose Destination
Science. 2011 Mar 11;331(6022):1322-5. doi: 10.1126/science.1197296. Epub 2011 Feb 17.

Mechanistic basis of resistance to PCBs in Atlantic tomcod from the Hudson River.

Author information

1
Department of Environmental Medicine, New York University School of Medicine,Tuxedo, NY 10987, USA. Isaac.wirgin@nyumc.org

Abstract

The mechanistic basis of resistance of vertebrate populations to contaminants, including Atlantic tomcod from the Hudson River (HR) to polychlorinated biphenyls (PCBs), is unknown. HR tomcod exhibited variants in the aryl hydrocarbon receptor 2 (AHR2) that were nearly absent elsewhere. In ligand-binding assays, AHR2-1 protein (common in the HR) was impaired as compared to widespread AHR2-2 in binding TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and in driving expression in reporter gene assays in AHR-deficient cells treated with TCDD or PCB126. We identified a six-base deletion in AHR2 as the basis of resistance and suggest that the HR population has undergone rapid evolution, probably due to contaminant exposure. This mechanistic basis of resistance in a vertebrate population provides evidence of evolutionary change due to selective pressure at a single locus.

PMID:
21330491
PMCID:
PMC3246799
DOI:
10.1126/science.1197296
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Secondary source ID, Grant support

Publication types

MeSH terms

Substances

Secondary source ID

Grant support

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center