Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Vasc Endovasc Surg. 2011 May;41(5):663-7. doi: 10.1016/j.ejvs.2011.01.009. Epub 2011 Feb 16.

Pharmacological interventions to attenuate the expansion of abdominal aortic aneurysm (AAA) - a systematic review.

Author information

1
Department of Surgical Sciences, Section of Surgery, Uppsala University Hospital, SE 751 85 Uppsala, Sweden. david.bergqvist@surgsci.uu.se

Abstract

INTRODUCTION:

Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms?

METHOD:

An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate.

RESULTS:

Of an original 450 articles, 21 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1069 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated.

CONCLUSION:

Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture.

PMID:
21330159
DOI:
10.1016/j.ejvs.2011.01.009
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center