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Biopolymers. 2011 Aug;95(8):543-9. doi: 10.1002/bip.21604. Epub 2011 Feb 15.

Time resolved SAXS and RNA folding.

Author information

1
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA. lp26@cornell.edu

Abstract

Small angle X-ray scattering provides low resolution structural information about macromolecules in solution. When coupled with rapid mixing methods, SAXS reports time-dependent conformational changes of RNA induced by the addition of Mg(2+) to trigger folding. Thus time-resolved SAXS provides unique information about the global or overall structures of transient intermediates populated during folding. Notably, SAXS provides information about the earliest folding events, which can evade detection by other methods.

PMID:
21328311
DOI:
10.1002/bip.21604
[Indexed for MEDLINE]
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