Format

Send to

Choose Destination
See comment in PubMed Commons below
Soc Psychiatry Psychiatr Epidemiol. 2012 Mar;47(3):455-64. doi: 10.1007/s00127-011-0353-0. Epub 2011 Feb 17.

Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: developmental timing matters.

Author information

1
Division of Women's Health, Department of Medicine, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital (BWH), One Brigham Circle, 1620 Tremont Street, Boston, MA 02120, USA.

Abstract

PURPOSE:

To examine how the timing of hypoxic exposure results in specific childhood outcomes and whether there is a differential effect by sex.

METHODS:

A sample of 10,879 prospectively followed pregnancies was drawn from the Boston and Providence sites (New England, NE) of the National Collaborative Perinatal Project. Based on placental pathology, we developed and validated a measure of probable chronic placental hypoxia (CHP) and contrasted the effects of acute perinatal hypoxia on age 7 emotional, behavioral, and cognitive outcomes.

RESULTS:

Perinatal hypoxia had a significant impact on multiple behavioral and cognitive outcomes in boys and girls by age 7, in contrast to probable CHP which had a differential effect on girls and boys such that there was decreased verbal IQ and increased inhibition in females alone.

CONCLUSIONS:

Findings underscore the importance of considering the timing of obstetric complications and offspring sex in investigations of the impact of fetal and perinatal hypoxia on offspring's outcomes throughout the life course.

PMID:
21327969
PMCID:
PMC3715145
DOI:
10.1007/s00127-011-0353-0
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center