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Appl Microbiol Biotechnol. 2011 May;90(4):1333-45. doi: 10.1007/s00253-011-3149-y. Epub 2011 Feb 16.

Isolation and characterisation of KP34--a novel φKMV-like bacteriophage for Klebsiella pneumoniae.

Author information

1
Institute of Genetics and Microbiology, University of Wrocław, Wrocław, Poland. zuzanna.drulis-kawa@microb.uni.wroc.pl

Abstract

Bacteriophage KP34 is a novel virus belonging to the subfamily Autographivirinae lytic for extended-spectrum β-lactamase-producing Klebsiella pneumoniae strains. Its biological features, morphology, susceptibility to chemical and physical agents, burst size, host specificity and activity spectrum were determined. As a potential antibacterial agent used in therapy, KP34 molecular features including genome sequence and protein composition were examined. Phylogenetic analyses and clustering of KP34 phage genome sequences revealed its clear relationships with "phiKMV-like viruses". Simultaneously, whole-genome analyses permitted clustering and classification of all phages, with completely sequenced genomes, belonging to the Podoviridae.

PMID:
21327407
PMCID:
PMC3082699
DOI:
10.1007/s00253-011-3149-y
[Indexed for MEDLINE]
Free PMC Article
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