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Transcription. 2010 Jul-Aug;1(1):27-31. doi: 10.4161/trns.1.1.12062.

Transcriptional regulation of the human telomerase reverse transcriptase: new insights.

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  • 1Université Claude Bernard - UMR, Oullins, France.

Abstract

hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments explains the link between hTERT expression and cell stimulation and offers new insights for therapeutic developments.

KEYWORDS:

NFAT; cell stimulation; hTERT; immunosuppression; tumorigenesis

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