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Transcription. 2010 Jul-Aug;1(1):32-5. doi: 10.4161/trns.1.1.12063.

Transcriptional regulation underlying recovery from a DNA damage-induced arrest.

Author information

1
UMC Utrecht, the Netherlands.

Abstract

When the DNA of a cell is damaged, cell cycle progression is arrested and cell cycle-specific transcription is inhibited. However, cell cycle-specific transcription is required for eventual recovery from the DNA damage-induced arrest. Here we discuss recent findings that demonstrate how transcription is fine-tuned during the DNA damage response and how this controls the capacity to recover from a DNA damage arrest in G(2) phase.

KEYWORDS:

DNA damage; FoxM1; G2/M; Wip1; checkpoint recovery; mitotic entry; recovery competence

PMID:
21327155
PMCID:
PMC3035183
DOI:
10.4161/trns.1.1.12063
[Indexed for MEDLINE]
Free PMC Article

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