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Bioeng Bugs. 2010 May-Jun;1(3):155-63. doi: 10.4161/bbug.1.3.10408. Epub 2009 Oct 23.

Development of a novel oral vaccine against Mycobacterium avium paratuberculosis and Johne disease: a patho-biotechnological approach.

Author information

1
Cork Institute of Technology, Bishopstown, Cork, Ireland.

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne disease, a granulomatous enteritis of cattle and other domesticated and wild ruminant species. Johne disease is prevalent worldwide and has a significant impact on the global agricultural economy. Current vaccines against Johne are insufficient in stemming its spread, and associated side-effects prevent their widespread use in control programs. Effective and safe vaccine strategies are needed. The main purpose of this paper is to propose and evaluate the development of a novel oral subunit-vaccine using a patho-biotechnological approach. This novel strategy, which harnesses patho-genetic elements from the intracellular pathogen Listeria monocytogenes, may provide a realistic route towards developing an effective next generation subunit vaccine against Johne disease and paratuberculosis.

KEYWORDS:

Johne disease; Listeria monocytogenes; paratuberculosis; patho-biotechnology; vaccine

PMID:
21326921
PMCID:
PMC3026420
DOI:
10.4161/bbug.1.3.10408
[Indexed for MEDLINE]
Free PMC Article
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