Format

Send to

Choose Destination
Transcription. 2011 Jan-Feb;2(1):28-31. doi: 10.4161/trns.2.1.13950.

Mediator and post-recruitment regulation of RNA polymerase II.

Author information

1
Department of Chemistry and Biochemistry, University of Colorado, Boulder, USA.

Abstract

The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.

KEYWORDS:

CDK8; DSIF; Myc; NELF; P-TEFb; p53; review

PMID:
21326907
PMCID:
PMC3023644
DOI:
10.4161/trns.2.1.13950
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center