Send to

Choose Destination
See comment in PubMed Commons below
Transcription. 2010 Nov;1(3):144-148. Epub 2010 Aug 17.

ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals.

Author information

Department of Medical Biochemistry and Microbiology; Uppsala University; Uppsala, Sweden.


A DNA transposon integrated into -the genome of a primitive mammal some 200 million years ago and, millions of years later, it evolved an essential function in the common ancestor of all placental mammals. This protein, now named ZBED6, was recently discovered because a mutation disrupting one of its binding sites, in an intron of the IGF2 gene, makes pigs grow more muscle. These findings have revealed a new mechanism for regulating muscle growth as well as a novel transcription factor that appears to be of major importance for transcriptional regulation in placental mammals.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center