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Transcription. 2010 Nov;1(3):144-148. Epub 2010 Aug 17.

ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals.

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1
Department of Medical Biochemistry and Microbiology; Uppsala University; Uppsala, Sweden.

Abstract

A DNA transposon integrated into -the genome of a primitive mammal some 200 million years ago and, millions of years later, it evolved an essential function in the common ancestor of all placental mammals. This protein, now named ZBED6, was recently discovered because a mutation disrupting one of its binding sites, in an intron of the IGF2 gene, makes pigs grow more muscle. These findings have revealed a new mechanism for regulating muscle growth as well as a novel transcription factor that appears to be of major importance for transcriptional regulation in placental mammals.

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