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Nat Rev Cancer. 2011 Mar;11(3):177-87. doi: 10.1038/nrc3003. Epub 2011 Feb 10.

Nucleating actin for invasion.

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1
Institute of Pharmacology, University of Marburg, Karl-von-Frisch-Str. 1, 35032 Marburg, Germany.

Abstract

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in metastasis, which is the leading cause of death from cancer. Invasive cell migration requires the formation of various structures, such as invadopodia and pseudopodia, which require actin assembly that is regulated by specialized actin nucleation factors. There is a large variety of different actin nucleators in human cells, such as formins, spire and Arp2/3-regulating proteins, and the list is likely to grow. Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide new treatments for invasive and metastatic disease.

PMID:
21326322
DOI:
10.1038/nrc3003
[Indexed for MEDLINE]
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