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Nat Rev Mol Cell Biol. 2011 Mar;12(3):152-62. doi: 10.1038/nrm3065. Epub 2011 Feb 16.

HTRA proteases: regulated proteolysis in protein quality control.

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1
Research Institute of Molecular Pathology, Dr. Bohrgasse 7, A-1030 Vienna, Austria. tim.clausen@imp.ac.at

Abstract

Controlled proteolysis underlies a vast diversity of protective and regulatory processes that are of key importance to cell fate. The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control. The simple combination of a classic Ser protease domain and a carboxy-terminal peptide-binding domain produces cellular factors of remarkable structural and functional plasticity that allow cells to rapidly respond to the presence of misfolded or mislocalized polypeptides.

PMID:
21326199
DOI:
10.1038/nrm3065
[Indexed for MEDLINE]
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