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Curr Opin Allergy Clin Immunol. 2011 Apr;11(2):86-9. doi: 10.1097/ACI.0b013e3283449fc9.

Genetics of occupational asthma.

Author information

1
Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. bernstdd@ucmail.uc.edu

Abstract

PURPOSE OF REVIEW:

To discuss gene association studies conducted in workers diagnosed with occupational asthma.

RECENT FINDINGS:

Human leukocyte antigen studies conducted in European workers have defined major histocompatibility complex class II alleles and haplotypes associated with diisocyanate asthma. Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanate asthma. Genotype combinations of IL-4 receptor-α and CD14 single nucleotide polymorphisms (SNPs) were significantly associated with diisocyanate asthma, but only in workers exposed to hexamethylene diisocyanate. A recent genome-wide association study (GWAS) conducted in Korea identified several SNPs of the α-T-catenin gene that were significantly associated with diisocyanate asthma.

SUMMARY:

Although candidate gene association studies have yet to identify reliable predictors of occupational asthma, future investigations including GWAS studies may identify high-risk genotypes allowing identification of workers at risk.

PMID:
21325943
DOI:
10.1097/ACI.0b013e3283449fc9
[Indexed for MEDLINE]
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