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Br J Psychiatry. 1990 Nov;157:735-9.

Neurological soft signs in schizophrenia.

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  • 1Psychiatric Clinic, University of L'Aquila, Ospedale di S. Maria di Collemaggio, Italy.


A standardised clinical examination which focused on neurological soft signs (NSS) was used by a neurologist blind to diagnosis to assess the presence of neurological soft signs. A comparison of NSS score was made among three groups of subjects consisting of 58 DSM-III schizophrenics, 31 of their healthy first-degree relatives and 38 normal controls. The schizophrenic group had significantly higher NSS total scores than normal controls but did not differ significantly from their first-degree relatives' group. The relatives' group showed higher NSS total scores than did normal controls although to a lesser extent than schizophrenics.

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