Format

Send to

Choose Destination
J Gen Virol. 2011 Jun;92(Pt 6):1358-68. doi: 10.1099/vir.0.028381-0. Epub 2011 Feb 16.

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells.

Author information

1
Microbiology Department, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Abstract

Understanding the mechanisms of augmented bacterial pathogenicity in post-viral infections is the first step in the development of an effective therapy. This study assessed the effect of human coronavirus NL63 (HCoV-NL63) on the adherence of bacterial pathogens associated with respiratory tract illnesses. It was shown that HCoV-NL63 infection resulted in an increased adherence of Streptococcus pneumoniae to virus-infected cell lines and fully differentiated primary human airway epithelium cultures. The enhanced binding of bacteria correlated with an increased expression level of the platelet-activating factor receptor (PAF-R), but detailed evaluation of the bacterium-PAF-R interaction revealed a limited relevance of this process.

PMID:
21325482
PMCID:
PMC3168281
DOI:
10.1099/vir.0.028381-0
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Ingenta plc Icon for PubMed Central
Loading ...
Support Center