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Dig Liver Dis. 2011 Jul;43(7):523-8. doi: 10.1016/j.dld.2010.12.016. Epub 2011 Feb 15.

The spectrum of drug-related colitides: important entities, though frequently overlooked.

Author information

1
2nd Pathology Department, Spedali Civili, Brescia, Italy.

Abstract

BACKGROUND:

There is at present a relative lack of knowledge concerning drug-related colitides, although these may be not infrequent entities in clinical practice.

AIMS:

To assess the frequency and the clinical-pathological subtypes of drug-related colitides in a gastrointestinal pathology referral centre.

METHODS:

All charts of endoscopic biopsy samples referred for colitis in a eight-year period were reviewed. To be classified as drug related colitis, patients' charts should report the use of any drug in a two month period before colonoscopy and no other obvious cases of colitis be present. For analysis, we considered only patients taking one drug in this period.

RESULTS:

We found 122 cases of drug-related colitis out of 3877 charts reviewed (3% of the overall colitis group). These cases were represented by microscopic colitis (50%), eosinophil rich infiltrate of the left colon (34%), ischemic colitis (11%), pseudomembranous colitis (3%), apoptotic colopathy (2%). The drugs most frequently associated with these colitides were represented by non-steroidal anti-inflammatory drugs.

CONCLUSION:

It is important to raise awareness concerning drug-related colitides, to avoid diagnostic errors and provide a better therapeutic approach to patients with these conditions.

PMID:
21324756
DOI:
10.1016/j.dld.2010.12.016
[Indexed for MEDLINE]

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