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Fertil Steril. 2011 Jun 30;95(8):2511-4. doi: 10.1016/j.fertnstert.2011.01.124. Epub 2011 Feb 16.

Endometrial LGR7 expression during menstrual cycle.

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Department of Obstetrics, Gynecology, and Reproductive Sciences, Second University of Naples, Naples, Italy.


In a prospective observational study, 50 healthy patients aged 18-39 years, with regular ovulatory cycle and normal hormone levels, underwent endometrial biopsy in the proliferative and secretory phase of the menstrual cycle for semiquantitative reverse-transcription polymerase chain reaction analysis of mRNA for LGR7, the classic relaxin receptor. LGR7 is constitutively expressed in human endometrium, and an increased LGR7 immunostaining is demonstrated in the secretory phase, confirming the involvement of relaxin in the physiology of endometrium and suggesting its role in implantation.

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