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Vaccine. 2011 Mar 24;29(15):2803-9. doi: 10.1016/j.vaccine.2011.01.108. Epub 2011 Feb 12.

A complex adenovirus vaccine against chikungunya virus provides complete protection against viraemia and arthritis.

Author information

1
Division of Biodefense Vaccines, GenPhar, Inc., Mount Pleasant, SC 29464, USA.

Abstract

Chikungunya virus, a mosquito-borne alphavirus, recently caused the largest epidemic ever seen for this virus. Chikungunya disease primarily manifests as a painful and debilitating arthralgia/arthritis, and no effective drug or vaccine is currently available. Here we describe a recombinant chikungunya virus vaccine comprising a non-replicating complex adenovirus vector encoding the structural polyprotein cassette of chikungunya virus. A single immunisation with this vaccine consistently induced high titres of anti-chikungunya virus antibodies that neutralised both an old Asian isolate and a Réunion Island isolate from the recent epidemic. The vaccine also completely protected mice against viraemia and arthritic disease caused by both virus isolates.

PMID:
21320541
PMCID:
PMC3061842
DOI:
10.1016/j.vaccine.2011.01.108
[Indexed for MEDLINE]
Free PMC Article

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