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BMC Psychiatry. 2011 Feb 14;11:26. doi: 10.1186/1471-244X-11-26.

Reduced antioxidant defense in early onset first-episode psychosis: a case-control study.

Author information

1
Department of Neuroscience, Pharmacology and Psychiatry, School of Medicine, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental. University of Cádiz, Spain.

Abstract

BACKGROUND:

Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group.

METHODS:

Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls.

RESULTS:

A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.

CONCLUSIONS:

Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.

PMID:
21320302
PMCID:
PMC3045298
DOI:
10.1186/1471-244X-11-26
[Indexed for MEDLINE]
Free PMC Article

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