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Nano Lett. 2011 Mar 9;11(3):1208-14. doi: 10.1021/nl1041947. Epub 2011 Feb 14.

Biomimetic high density lipoprotein nanoparticles for nucleic acid delivery.

Author information

1
Department of Urology, Feinberg School of Medicine, Northwestern University , 303 East Chicago Avenue, Tarry 16-703, Chicago, Illinois 60611, United States.

Abstract

We report a gold nanoparticle-templated high density lipoprotein (HDL AuNP) platform for gene therapy that combines lipid-based nucleic acid transfection strategies with HDL biomimicry. For proof-of-concept, HDL AuNPs are shown to adsorb antisense cholesterylated DNA. The conjugates are internalized by human cells, can be tracked within cells using transmission electron microscopy, and regulate target gene expression. Overall, the ability to directly image the AuNP core within cells, the chemical tailorability of the HDL AuNP platform, and the potential for cell-specific targeting afforded by HDL biomimicry make this platform appealing for nucleic acid delivery.

PMID:
21319839
PMCID:
PMC4077779
DOI:
10.1021/nl1041947
[Indexed for MEDLINE]
Free PMC Article

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