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J Dent Res. 2011 Apr;90(4):433-8. doi: 10.1177/0022034510387795. Epub 2011 Feb 11.

ONJ in two dental practice-based research network regions.

Author information

1
Kaiser Permanente Center for Health Research, 3800 N Interstate Ave, Portland, OR 97227, USA. jeffrey.fellows@kpchr.org

Abstract

The incidence of osteonecrosis of the jaw (ONJ) in the population is low, but specifics are unknown. Potential risk factors include bisphosphonate treatment, steroid treatment, osteoporosis, and head/neck radiation. This Dental Practice-Based Research Network study estimated ONJ incidence and odds ratios from bisphosphonate exposure and other risk factors using a key word search and manual chart reviews of electronic records for adults aged ≥ 35 yrs enrolled during 1995-2006 in two large health-care organizations. We found 16 ONJ cases among 572,606 cohort members; seven additional cases were identified through dental plan resources. Among 23 cases (0.63 per 100,000 patient years), 20 (87%) had at least one risk factor, and six (26%) had received oral bisphosphonates. Patients with oral bisphosphonates were 15.5 (CI, 6.0-38.7) more likely to have ONJ than non-exposed patients; however, the sparse number of ONJ cases limits firm conclusions and suggests that the absolute risks for ONJ from oral bisphosphonates is low.

PMID:
21317245
PMCID:
PMC3144130
DOI:
10.1177/0022034510387795
[Indexed for MEDLINE]
Free PMC Article

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