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Bioorg Med Chem Lett. 2011 Mar 15;21(6):1716-8. doi: 10.1016/j.bmcl.2011.01.080. Epub 2011 Jan 22.

Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus.

Author information

1
Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon, Republic of Korea.

Abstract

A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC(50) of 6 μM and also showed antibacterial activity against S. aureus and MRSA.

PMID:
21316961
DOI:
10.1016/j.bmcl.2011.01.080
[Indexed for MEDLINE]

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