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Cancer Cell. 2011 Feb 15;19(2):163-5. doi: 10.1016/j.ccr.2011.01.045.

Monoallelic deletion of NFKBIA in glioblastoma: when less is more.

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1
Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Bredel et al. (2010) recently identified a subset of glioblastomas that harbor monoallelic loss of NFKBIA, which negatively affects patient prognosis. This finding raises new questions as to the role of IκBα and NF-κB in glioblastoma, the relationship between EGFR and NF-κB signaling, and potential therapeutic targets.

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PMID:
21316598
DOI:
10.1016/j.ccr.2011.01.045
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