Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2011 Apr;21(2):160-6. doi: 10.1016/j.gde.2011.01.011.

Lessons on transcriptional control from the serum response network.

Author information

1
Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, CO, United States.

Abstract

Response to environmental stimuli is critical for cell survival and function and requires high fidelity signal transduction into the nucleus to facilitate the coordinated transcriptional regulation of appropriate gene networks. The cellular response to mitogenic stimuli provides an excellent paradigm to decipher the mechanisms mediating precise gene expression control at the transcriptional level. Here we review recent advances in our understanding of this so-called serum response network, which illuminate novel aspects of nuclear signaling mechanisms, combinatorial control by DNA binding proteins and regulation of RNA polymerase II (RNAPII) elongation.

PMID:
21316215
PMCID:
PMC3070842
DOI:
10.1016/j.gde.2011.01.011
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center