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J Neuroimmunol. 2011 May;234(1-2):124-30. doi: 10.1016/j.jneuroim.2011.01.007. Epub 2011 Feb 11.

Temporal dynamics of cerebrospinal fluid anti-aquaporin-4 antibodies in patients with neuromyelitis optica spectrum disorders.

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1
Clinic of Neurology, Clinical Center of Serbia, Belgrade, Serbia.

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) are associated with anti-aquaporin-4 autoantibodies (AQP4-IgG). Limited data is available on longitudinal cerebrospinal fluid (CSF) AQP4-IgG and their relation to disease activity and inflammatory parameters. AQP4-IgG titers were measured in matched longitudinal serum and CSF samples of 12 patients with NMOSD by an immunofluorescence assay and correlated with clinical parameters. CSF AQP4-IgG were present in patients with high serum titers and correlated with spinal MRI lesion length and CSF parameters. Clinical improvement was associated with a decrease in CSF, but not serum, AQP4-IgG titers. Thus, CSF AQP4-IgG were associated with clinical activity and neuroinflammation.

PMID:
21316112
DOI:
10.1016/j.jneuroim.2011.01.007
[Indexed for MEDLINE]
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