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J Am Acad Dermatol. 2011 Mar;64(3):455-72; quiz 473-4. doi: 10.1016/j.jaad.2010.03.044.

Superantigens in dermatology.

Author information

1
Department of Dermatology, New York Medical College, New York, New York 10029, USA. edgarmacias79@gmail.com

Abstract

Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs. They are linked to a variety of conditions, ranging from toxic shock syndrome to recurrent toxin-mediated perineal erythema. The early recognition of signs and symptoms of SAg-mediated illnesses is important to ensure prompt medical treatment.

PMID:
21315950
DOI:
10.1016/j.jaad.2010.03.044
[Indexed for MEDLINE]

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