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Mol Cell Probes. 2011 Apr-Jun;25(2-3):130-3. doi: 10.1016/j.mcp.2011.01.003. Epub 2011 Feb 15.

High-resolution melting curve analysis to establish CYP2C19∗2 single nucleotide polymorphism: Comparison with hydrolysis SNP analysis.

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1
Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri 59-67, H-1025 Budapest, Hungary. m.temesvari@chemres.hu

Abstract

Clinically significant consequences of CYP2C19 polymorphism in drug metabolism require reliable genotyping methods for assaying large numbers of blood samples. Hydrolysis single nucleotide polymorphism analysis and high-resolution melting curve (HRM) analysis successfully genotyped the 114 liver donors for CYP2C19∗2. However, the HRM analysis was found to be more efficient, rapid, user- and cost-friendly method.

PMID:
21315147
DOI:
10.1016/j.mcp.2011.01.003
[Indexed for MEDLINE]
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