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Cancer Invest. 2011 Mar;29(3):240-5. doi: 10.3109/07357907.2010.550594.

Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.

Author information

1
Department of Dermatology, Aarhus University Hospital, Denmark.

Abstract

Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation.

PURPOSE:

To examine the role of MSK1/2 in skin tumor development.

RESULTS:

MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1β as well as the mRNA expression of TNF-α were significantly increased in MSK1/2 knockout mice.

CONCLUSION:

These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.

PMID:
21314333
DOI:
10.3109/07357907.2010.550594
[Indexed for MEDLINE]

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