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Clin Neurophysiol. 2011 Jul;122(7):1327-32. doi: 10.1016/j.clinph.2011.01.007. Epub 2011 Feb 9.

EEG coherence and symptom profiles of children with Attention-Deficit/Hyperactivity Disorder.

Author information

1
Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong, NSW 2522, Australia. robert_barry@uow.edu.au

Abstract

OBJECTIVE:

We compared EEG coherence in children with and without AD/HD, and sought to relate observed anomalies to AD/HD symptoms.

METHODS:

Forty children with AD/HD and 40 age- and sex-matched controls had eyes-closed resting EEG coherence calculated for eight interhemispheric electrode pairs and eight intrahemispheric pairs (four within each hemisphere) in the delta, theta, alpha, beta and "40 Hz" gamma bands.

RESULTS:

At short-medium inter-electrode distances, the AD/HD group had increased intrahemispheric coherence in delta and theta, and reduced (L>R) laterality in delta, alpha, beta and gamma. Over longer inter-electrode distances, the AD/HD group had reduced intrahemispheric coherence in alpha. In interhemispheric comparisons, the AD/HD group had reduced frontal coherence in delta, alpha and gamma, increased temporal theta and reduced temporal alpha coherences, and increased central/parietal/occipital coherence in theta. Smaller left-lateralized coherences in AD/HD correlated negatively with DSM Inattentive and DSM Total scores, and smaller frontal interhemispheric coherence in alpha correlated negatively with DSM Hyperactive/Impulsive score.

CONCLUSIONS:

The negative correlations between AD/HD coherence anomalies and symptoms suggest that several anomalies reflect compensatory brain function.

SIGNIFICANCE:

Coherence differences in AD/HD may reflect anomalous frontal right-hemisphere linkages that help compensate functional brain anomalies in the left frontal regions in this disorder.

PMID:
21310652
DOI:
10.1016/j.clinph.2011.01.007
[Indexed for MEDLINE]

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