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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Apr;111(4):456-60. doi: 10.1016/j.tripleo.2010.10.043.

Commercial mouthwashes are more effective than azole antifungals against Candida albicans biofilms in vitro.

Author information

1
Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. gordon.ramage@glasgow.ac.uk

Abstract

OBJECTIVE:

The aim of this study was to evaluate and compare the activity of prescription and over-the-counter antimicrobial compounds against planktonic and biofilm forms of Candida albicans isolated from cases of oral candidiasis in vitro.

STUDY DESIGN:

The efficacy of azoles, polyenes, an echinocandin, and 4 over-the-counter mouthwashes were tested against C. albicans-derived planktonic and biofilm cells.

RESULTS:

Planktonic cells were shown to be highly sensitive to all of the antifungal agents tested. Sessile cells were highly resistant to azoles (≥128 mg/L) but equally sensitive to caspofungin and short treatments with Corsodyl, Listerine, and Oraldene.

CONCLUSIONS:

Although C. albicans is sensitive to azole antifungal agents in planktonic form, it is highly resistant within the biofilm. The good efficacy of the over-the-counter mouthwashes against candidal biofilms in vitro suggests that clinical trials should now be designed to establish their role in the clinical management of oral candidal infections.

PMID:
21310633
DOI:
10.1016/j.tripleo.2010.10.043
[Indexed for MEDLINE]

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