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Bioorg Med Chem Lett. 2011 Mar 1;21(5):1354-8. doi: 10.1016/j.bmcl.2011.01.043. Epub 2011 Jan 18.

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules.

Author information

1
Theravance, Inc., South San Francisco, CA 94080, USA. ahughes@theravance.com

Abstract

We sought to design dual pharmacology bronchodilators targeting both the M(3) muscarinic acetylcholine and beta-2 adrenergic (β(2)) receptors by applying our multivalent approach to drug discovery. Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.

PMID:
21310610
DOI:
10.1016/j.bmcl.2011.01.043
[Indexed for MEDLINE]

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