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Dev Neurobiol. 2012 Mar;72(3):346-57. doi: 10.1002/dneu.20874.

Imaging circuit formation in zebrafish.

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King's College London, Guy's Hospital Campus, London SE1 1UL, UK.


The study of nervous system development has been greatly facilitated by recent advances in molecular biology and imaging techniques. These approaches are perfectly suited to young transparent zebrafish where they have allowed direct observation of neural circuit assembly in vivo. In this review we will highlight a number of key studies that have applied optical and genetic techniques in zebrafish to address questions relating to axonal and dendritic arbor development,synapse assembly and neural plasticity. These studies have revealed novel cellular phenomena and modes of growth that may reflect general principles governing the assembly of neural circuits.

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