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Chem Commun (Camb). 2011 Mar 14;47(10):2790-2. doi: 10.1039/c0cc05776b. Epub 2011 Feb 9.

Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide.

Author information

1
Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.

Abstract

We found that Hoogsteen base pairs were stabilized by molecular crowding and a histone H3-mimicking peptide, which was not observed for Watson-Crick base pairs. Our findings demonstrate that the type of DNA base pair is critical for the interaction between DNA and histones.

PMID:
21308127
DOI:
10.1039/c0cc05776b
[Indexed for MEDLINE]

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