Send to

Choose Destination
See comment in PubMed Commons below
Schizophr Bull. 2011 Mar;37(2):238-43. doi: 10.1093/schbul/sbq165. Epub 2011 Feb 9.

Dysfunctional thalamus-related networks in schizophrenia.

Author information

Inserm u666, Pathophysiology and Psychopathology of Schizophrenia, IFR37, Faculty of Medicine, University of Strasbourg, Strasbourg, France.


Thalamus abnormalities are common in neurological and psychiatric illnesses. Therefore, it is essential to understand the properties of the thalamus-related networks. The thalamic reticular nucleus (TRN) is a thin GABAergic layer interface strategically located between the thalamus and the neocortex. It is, at the very beginning of life, an essential neurodevelopmental guide for the accurate build up of reciprocal anatomical glutamatergic connections between the thalamus and neocortex. It is more than the mediator of selective attention. It appears as a combinatorial matrix because it holds and can combine multiple functional modalities. TRN cells work like integrators, thanks to their extraordinary intrinsic electrophysiological properties, under the contextual and leading influence of corticothalamic inputs. The TRN and thalamus principally form 2-neuron open-loop circuits (no reciprocal connection). The major functioning principle of such GABAergic-glutamatergic circuits is lateral inhibition, which is a gold standard device to set up, via differential amplifications, coherent structured thalamocortical activity patterns. Thereby, it selects relevant streams of information and deletes distractors during action, resting states, and information integration, including during consciousness, cognition, emotion, and thought. Disruption of thalamic lateral inhibition may contribute to a lack of coordination in activity between brain regions, as observed in psychiatric disorders like schizophrenia.

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center