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Biol Direct. 2011 Feb 9;6:8. doi: 10.1186/1745-6150-6-8.

Evolutionary patterns of phosphorylated serines.

Author information

1
Institute for Information Transmission Problems (Kharkevich Institute) RAS, Bolshoi Karetny pereulok 19, Moscow, 127994, Russia.

Abstract

Posttranslationally modified amino acids are chemically distinct types of amino acids and in terms of evolution they might behave differently from their non-modified counterparts. In order to check this possibility, we reconstructed the evolutionary history of phosphorylated serines in several groups of organisms. Comparisons of substitution vectors have revealed some significant differences in the evolution of modified and corresponding non-modified amino acids. In particular, phosphoserines are more frequently substituted to aspartate and glutamate, compared to non-phosphorylated serines.

PMID:
21306633
PMCID:
PMC3044110
DOI:
10.1186/1745-6150-6-8
[Indexed for MEDLINE]
Free PMC Article

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