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Muscle Nerve. 2011 Mar;43(3):415-24. doi: 10.1002/mus.21913. Epub 2011 Feb 8.

Muscle endurance, cancer-related fatigue, and radiotherapy in prostate cancer survivors.

Author information

1
Exercise Science Program, Marquette University, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, USA.

Abstract

INTRODUCTION:

In this study we investigated muscle and cancer-related fatigue (CRF) in prostate cancer survivors (CS) undergoing radiotherapy (RT).

METHODS:

In 13 CS and 12 controls, CRF was assessed by the Piper Fatigue Scale (PFS), Epworth Sleepiness Scale--Depression subscale (CES-D), physical activity (accelerometer), and hemoglobin levels (Hb). Muscle measures included strength, activation, contractile properties, and endurance during intermittent dorsiflexion. Testing occurred before and after 6 weeks of RT in CS.

RESULTS:

After RT, the PFS score increased from initial levels in CS only without changes in sleepiness, depression, or physical activity. Hb decreased in CS only [mean (SD): pre, 15 (1.1); post, 14.5 (1.1) g/dl; P = 0.04]. Endurance decreased in CS [mean (SD): pre, 519 (340) s; post, 388 (203) s; P = 0.04] and increased in controls [mean (SD: pre, 616 (387) s; post, 753 (553) s; P = 0.03]. Only endurance was associated with PFS in CS (r = -0.55, P = 0.05).

DISCUSSION:

Muscle endurance is impaired after RT and may contribute to CRF in CS.

PMID:
21305569
DOI:
10.1002/mus.21913
[Indexed for MEDLINE]

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