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Eur J Hum Genet. 2011 Jun;19(6):667-71. doi: 10.1038/ejhg.2010.257. Epub 2011 Feb 9.

Identification of regions of positive selection using Shared Genomic Segment analysis.

Author information

1
Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. z.cai@utah.edu

Abstract

We applied a shared genomic segment (SGS) analysis, incorporating an error model, to identify complete, or near complete, selective sweeps in the HapMap phase II data sets. This method is based on detecting heterozygous sharing across all individuals within a population, to identify regions of sharing with at least one allele in common. We identified multiple interesting regions, many of which are concordant with positive selection regions detected by previous population genetic tests. Others are suggested to be novel regions. Our finding illustrates the utility of SGS as a method for identifying regions of selection, and some of these regions have been proposed to be candidate regions for harboring disease genes.

PMID:
21304558
PMCID:
PMC3110045
DOI:
10.1038/ejhg.2010.257
[Indexed for MEDLINE]
Free PMC Article

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