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Nat Rev Neurosci. 2011 Mar;12(3):127-38. doi: 10.1038/nrn2948. Epub 2011 Feb 9.

Protein scaffolds in the coupling of synaptic exocytosis and endocytosis.

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Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität, and Charité Universitätsmedizin Berlin, Takustraße 6, 14195 Berlin, Germany. volker.haucke@fu‑


Mechanisms that ensure robust long-term performance of synaptic transmission over a wide range of activity are crucial for the integrity of neuronal networks, for processing sensory information and for the ability to learn and store memories. Recent experiments have revealed that such robust performance requires a tight coupling between exocytic vesicle fusion at defined release sites and endocytic retrieval of synaptic vesicle membranes. Distinct presynaptic scaffolding proteins are essential for fulfilling this requirement, providing either ultrastructural coordination or acting as signalling hubs.

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