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Indian J Med Microbiol. 2011 Jan-Mar;29(1):19-21. doi: 10.4103/0255-0857.76518.

BinaxNOW® - an immunochromatographic test for the diagnosis of human influenza viruses: comparison with viral culture and polymerase chain reaction.

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1
HPA West Midlands Public Health Laboratory, Birmingham Heartlands Hospital, UK.

Abstract

PURPOSE:

A rapid test for influenza viruses (Binax NOW® ) was evaluated.

MATERIALS AND METHODS:

In season-1, 35 respiratory samples were tested retrospectively; in season-2, 45 samples were tested prospectively [gold-standard: viral culture in season-1, culture+ reverse transcriptase-polymerase chain reaction (RT-PCR) in season-2].

RESULTS:

Sensitivity for Binax for influenza A was 59.3 and 0% in season-1 and -2, respectively. Sensitivity was low for influenza B (33.3% in season-1, 26.1% in season-2). Samples having low viral load were more likely to have a negative Binax test. Specificity of Binax was high (100 and 94.7% with influenza A and B, respectively).

CONCLUSION:

Sensitivity information provided in the kit insert does not always reflect post licensure performance in clinical settings.

PMID:
21304189
DOI:
10.4103/0255-0857.76518
[Indexed for MEDLINE]
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