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Biomarkers. 2011 Mar;16(2):172-80. doi: 10.3109/1354750X.2010.541564. Epub 2011 Feb 8.

Plasma netrin-1 is a diagnostic biomarker of human cancers.

Author information

1
Department of Medicine/Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA. gramesh@mcg.edu

Abstract

CONTEXT:

The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues.

OBJECTIVES:

To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer.

MATERIALS AND METHODS:

A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry.

RESULTS:

Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples.

DISCUSSION AND CONCLUSION:

Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.

PMID:
21303223
PMCID:
PMC3143477
DOI:
10.3109/1354750X.2010.541564
[Indexed for MEDLINE]
Free PMC Article
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