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J Neurovirol. 2011 Apr;17(2):153-8. doi: 10.1007/s13365-011-0018-5. Epub 2011 Feb 8.

Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.

Author information

1
Department of Radiology, Northwestern University, 737 N. Michigan Avenue, Suite 1600, Chicago, IL 60611-2927, USA. ann-ragin@northwestern.edu

Abstract

Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.

PMID:
21302026
PMCID:
PMC3771512
DOI:
10.1007/s13365-011-0018-5
[Indexed for MEDLINE]
Free PMC Article

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