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Lab Chip. 2011 Apr 7;11(7):1280-5. doi: 10.1039/c0lc00527d. Epub 2011 Feb 8.

Recent advances in particle and droplet manipulation for lab-on-a-chip devices based on surface acoustic waves.

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Department of Mechanical Engineering, University of Akron, 302 Buchtel Common, Akron, Ohio 44325-3903, USA.


Manipulation of microscale particles and fluid liquid droplets is an important task for lab-on-a-chip devices for numerous biological researches and applications, such as cell detection and tissue engineering. Particle manipulation techniques based on surface acoustic waves (SAWs) appear effective for lab-on-a-chip devices because they are non-invasive, compatible with soft lithography micromachining, have high energy density, and work for nearly any type of microscale particles. Here we review the most recent research and development of the past two years in SAW based particle and liquid droplet manipulation for lab-on-a-chip devices including particle focusing and separation, particle alignment and patterning, particle directing, and liquid droplet delivery.

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