Send to

Choose Destination
Phys Biol. 2011 Feb;8(1):015016. doi: 10.1088/1478-3975/8/1/015016. Epub 2011 Feb 7.

The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view.

Author information

Integrated Mathematical Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.


Recent advances in clinical medicine have elucidated two significantly different subtypes of glioblastoma which carry very different prognoses, both defined by mutations in isocitrate dehydrogenase-1 (IDH-1). The mechanistic consequences of this mutation have not yet been fully clarified, with conflicting opinions existing in the literature; however, IDH-1 mutation may be used as a surrogate marker to distinguish between primary and secondary glioblastoma multiforme (sGBM) from malignant progression of a lower grade glioma. We develop a mathematical model of IDH-1 mutated secondary glioblastoma using evolutionary game theory to investigate the interactions between four different phenotypic populations within the tumor: autonomous growth, invasive, glycolytic, and the hybrid invasive/glycolytic cells. Our model recapitulates glioblastoma behavior well and is able to reproduce two recent experimental findings, as well as make novel predictions concerning the rate of invasive growth as a function of vascularity, and fluctuations in the proportions of phenotypic populations that a glioblastoma will experience under different microenvironmental constraints.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for IOP Publishing Ltd. Icon for PubMed Central
Loading ...
Support Center