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Antimicrob Agents Chemother. 2011 May;55(5):2403-5. doi: 10.1128/AAC.00082-11. Epub 2011 Feb 7.

Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni.

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1
Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France.

Abstract

Trioxaquine PA1259 is an efficient drug on larval- and adult-stage schistosomes, able to alkylate heme inside worms treated with it, leading to the formation of covalent heme-drug adducts. Such a mechanism, similar to one reported for other trioxaquines in Plasmodium, indicates that heme may be a common target of these trioxane-based drugs in different blood-feeding parasites.

PMID:
21300841
PMCID:
PMC3088258
DOI:
10.1128/AAC.00082-11
[Indexed for MEDLINE]
Free PMC Article
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