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Med Clin (Barc). 2011 Apr 9;136(9):382-5. doi: 10.1016/j.medcli.2010.05.033.

[Impaired fasting glucose and risk of diabetes mellitus at 10 years. Cohort study].

[Article in Spanish]

Author information

1
Centro de Salud La Marina, Barcelona, España. jbaenad@meditex.es

Abstract

BACKGROUND AND OBJECTIVE:

The aim of this study was to define the incidence of type 2 diabetes mellitus in patients with impaired fasting glucose and its association with risk factors.

PATIENTS AND METHOD:

115 patients aged > 18 years old, randomly selected in a Healthcare Center, diagnosed of impaired fasting glucose with 1997 American Diabetes Association criteria, followed 10 years. Predictive factors for developing diabetes mellitus were: age, sex, smoking, hypertension, hypercholesterolemia, family history of type 2 diabetes mellitus, antecedent of diabetes in pregnancy, and obesity.

RESULTS:

During the 10 years of follow-up, 33 patients developed type 2 diabetes mellitus (28.7%; 95% CI 20.4-37.0%), 57 patients progressed to normoglycaemia (49.6%; 95% CI 40.4-58.7%), and 25 patients remained with an impaired fasting glucose (21.7%; 95% CI 14.2-29.3%). Only obesity was associated with progression to type 2 diabetes mellitus (adjusted hazard ratio 2.01; 95% CI 1.00-4.03, p=0.050).

CONCLUSIONS:

Half of the patients with impaired fasting glucose normalized their glycaemia, and 28.7% developed diabetes mellitus, especially patients with obesity. These results suggest a different natural history to respect glucose intolerance.

PMID:
21300382
DOI:
10.1016/j.medcli.2010.05.033
[Indexed for MEDLINE]
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